No one is particularly fond of taking medication. It's not for everyone. However, there are times when nothing else has worked, despite your best effort. That's when it's time to consider taking the next step. Chemical care is not a silver bullet, it's complicated and it can be tricky. If you're taking medication it's like building a building. There's a blue-print, a foundation, scaffolding and a certain order in which you have to do things. It matters, when you take it. It matters how you take it. So, it's not something you take lightly.
All psychedelics stimulate serotonin circuits, specifically via 5HT2a receptors. As such they have powerful effects on mood, visual-spatial representations and decrease voltage in the DMN, Default Mode Network, through which they decrease 'ego'.
Cannabis comes in two strains with radically different effects: Sativa and Indica. Beyond that cannabis can be processed to yield specific chemicals with very different effects: THC and CBD and various other 'cannabinoids'.